If you have kids, what about having the kids create artwork for them.
This year I am giving my 6 year old 8×10 canvases and letting her have her way with them and my acrylic paint as gifts for the grandparents.
But other options are paper and whatever art supplies you have on hand.
Of course my mother in law’s gift is being supplimented with a T-shirt my husband and his brother bought at the Spam-a-lot musical that says “I’m not dead yet”. But their mother is kinda odd and will love it. She did raise the boys on Dr. Demento.